CAST® Leukotriene ELISA
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IgE tests and skin prick tests are the most common allergy tests in the US, although neither offers 100% specificity or sensitivity. There are many occasions where these tests are simply not appropriate (i.e. pediatric patients). The CAST® Leukotriene ELISA, a test commonly used in Europe by clinicians and researchers, is now available in the United States exclusively from ALPCO Diagnostics and is a great alternative means of allergy diagnosis. The CAST® Leukotriene  ELISA is the first test which detects de novo cysteinyl leukotrienes (LTC4, LTD4, and LTE4) in whole blood with excellent sensitivity and specificity.

The most common allergies involve antibodies of the IgE class. When people experience an allergic reaction, cross-linked antibodies like IgE cause leukocytes to release mediators such as leukotrienes. Leukotrienes are involved with common allergic symptoms like bronchoconstriction, smooth muscle contraction, increased capillary permeability and sometimes even anaphylaxis. It is the release of these mediators that cause the allergic reaction, and not the mere presence of IgE. For this reason, tests that measure these mediators better illustrate the actual allergic reaction than IgE tests.

Results with the CAST® Leukotriene ELISA can easily be determined the same day utilizing the same ELISA techniques and equipment already used in most labs. In addition, it offers qualitative and quantitative data, so results not only demonstrate sensitization to an allergen, but also the intensity of the allergic reaction. CAST® Leukotriene ELISA is especially valuable because it is successful at detecting both IgE mediated and non-IgE mediated allergies (pseudo-allergies).

Who may benefit from utilizing CAST® Leukotriene ELISA?
Scientists in many industries have utilized CAST® Leukotriene ELISA to detect leukotrienes for a variety of applications. Examples include:

• Diagnosis of IgE-mediated allergies

• Diagnosis of pseudo-allergies (non-IgE mediated)

• Pediatric allergy testing

• Detection of food allergies

• Detection of drug allergies

• Monitoring immunotherapy

The CAST® Leukotriene ELISA has been used successfully all over the world for the detection of cysteinyl leukotrienes using many different allergens. Over 100 different allergens are available from ALPCO Diagnostics and are specially produced for use in this assay, but novel allergens can be used as well. Available allergens include:

• Latex

• Mites and Insects

• Pollen from grass, weeds, trees

• Drugs like analgesics, antibiotics, and anesthetics

• Food/Food Additive

• For a full list of available allergens,

Why choose CAST® Leukotriene ELISA?

• Results better reflect actual allergic status

• Detects both IgE and Non-IgE mediated allergies

• FAST Results - The same day

• Utilizes standard techniques and equipment

• A library of over 100 allergens are available

• Results are both qualitative and quantitative

• Same cutoff point for every allergen

TEST FEATURES:

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CONTACT INFORMATION
Call to find out how to receive 20% off your first order of CAST® Leukotriene ELISA or for protocols, or pricing, please call 1-800-592-5726 x 222..